In vitro metabolism of synthetic cannabinoid AM1220 by human liver microsomes and Cunninghamella elegans employing liquid chromatography coupled with higher resolution mass spectrometry
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Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-style calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor
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Rat brain cannabinoid receptor was stably transfected into your murine tumor line AtT-20 to study its coupling to inwardly rectifying potassium currents and large voltage-activated calcium currents and an endogenous cannabinoid, anandamide, activated Kir and inhibited ICa as efficaciously as potent cannabinoid agonist.
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Potency ratios and ninety five% CLs would be the ED50 values of rimonabant together Along with the agonist divided by the ED50 price of rimonabant on your own.
In vitro benefits suggest that AM-2201 has to be examined for opportunity pharmacokinetic drug interactions in vivo because of its powerful inhibition of CYP2C8, CYP3A4, UGT1A3, and UGT2B7 enzyme functions.
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Strong inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups inside the resorcinol moiety.